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Ulla Haverinen Mikko Vahteristo Juha Pekkanen Tuula Husman Aino Nevalainen Demetrios Moschandreas 《Environmental Modeling and Assessment》2003,8(4):303-309
An empirical moisture damage index was developed in order to reduce the subjectivity of the estimation of moisture damage in domestic residences, in relation to occupant health. The database was generated using information gathered from a sample of 164 houses that were examined by civil engineers, and questionnaire data collected from the occupants. The index was formulated to associate with the occupant reported respiratory symptoms by calculating weighted estimates of selected moisture damage attributes using 80% of the sample. The remaining 20% of the sample was used to verify the final index. The index associated strongly with the health symptoms of interest. This index is a tool that may be used as an indicator of moisture damage induced exposure in domestic residences. 相似文献
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A pleural effusion associated with congenital pulmonary lymphangiectasia was detected in a fetus in utero but was absent at the time of delivery. The pleural effusion was unilateral although the disease involved both lungs. In this case there was an association between polyhydramnios and congenital pulmonary lymphangiectasia. 相似文献
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Tamás Marton Júlia Hajdú Csaba Papp Péter Patkós Ervin Hruby Zoltán Papp 《黑龙江环境通报》2001,21(6):452-456
The present study describes an association between adverse outcome in the twin-to-twin transfusion syndrome (TTTS) and pulmonary stenosis or reactive right ventricular hypertrophy. Six discordant monozygotic twin pregnancies with TTTS are described. Ventricular hypertrophy and atrioventricular valvular regurgitation occurred in all the recipient twins with pulmonary valvular stenosis in three cases and infundibular stenosis in one case. The recipient twin in one pair and both twins in another pregnancy died as a consequence of immaturity but the remaining twins all survived. Surgical intervention was required in one baby for valvular pulmonary stenosis. Our observations suggest that elevated blood pressure in the transfusion recipient may play an important role in pathogenesis. We hypothesise that both pulmonary stenosis and right chamber hypertrophy are secondary to hemodynamic changes. Although we have found valvular pulmonary stenosis in three recipients and infundibular stenosis in only one, this (obstruction to outflow) could be due to right chamber hypertrophy. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
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Rita W. Driggers Helene Bernstein Michael Lantz Gail Stetten Cathleen S. Escallon Elizabeth Perlman Karin J. Blakemore 《黑龙江环境通报》2001,21(5):387-389
Non-mosaic trisomy 20 is rare in fetuses surviving beyond the first trimester. We report a case of a fetus with non-mosaic trisomy 20 in amniotic fluid cultures obtained during the prenatal evaluation of an unusual thoraco-abdominal mass which was found at autopsy to be pulmonary sequestration. Gross inspection and autopsy of the fetus revealed multiple anomalies. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
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An immunology-based in vivo screening regime was used to assess the potential pathogenicity of biotechnology-related microbes. Strains of Bacillus cereus (Bc), Bacillus subtilis (Bs), Bacillus thuringiensis (Bt), and Bt commercial products (CPs) were tested. Balb/c mice were endotracheally instilled with purified spores, diluted CP, or vegetative cells (VC) (live or dead). Exposed mice were evaluated for changes in behavioral and physical symptoms, bacterial clearance, pulmonary granulocytes, and pulmonary and circulatory pyrogenic cytokines (interleukins (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α), as well as acute phase biomarkers (fibrinogen and serum amyloid A). Except for some differences in clearance rates, no marked effects were observed in mice exposed to any spore at 106 or 107 colony forming units (cfu). In contrast, live Bc or Bt VCs (105 or 106?cfu) produced shock-like symptoms (lethargy, hunched appearance, ruffled fur, and respiratory distress), and 11–200-fold elevations in pyrogenic cytokines at 2-h post-exposure. In the study, 4-h effects included increased lethargy, ocular discharge, and 1.5–4-fold rise in circulatory acute phase markers, but no indications of recovery. Bs VC did not produce any changes in symptoms or biomarkers. After 2 or 4?h of exposure to dead VC, increases of only plasma IL-1β and TNF-α (4.6- and 12.4-fold, respectively) were observed. These findings demonstrate that purified spores produced no marked effects in mice compared to that of metabolically active bacteria. This early screening regime was successful in distinguishing the pathogenicity of the different Bacillus species, and might be useful for assessing the relative hazard potential of other biotechnology-related candidate strains. 相似文献
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Shilpa Gantedi 《毒物与环境化学》2013,95(9):1768-1779
In this study, we have evaluated the ability of zinc oxide (ZnO) nanoparticles to induce pulmonary and extrapulmonary toxicities was examined in rats following intratracheal (IT) instillation. Lungs of rats were instilled IT with either phosphate-buffered saline (PBS)?+?1% Tween 80, ZnO nanoparticles, carbonyl iron or quartz particles at a dose of 1 or 5?mg?kg?1 body weight. Following exposure, bronchoalveolar lavage (BAL) fluid, blood samples and organs including lung, liver, kidneys, heart, pancreas, and brain were collected at 24?h, 1 week, or 1 month of post instillation of nanoparticles and different parameters estimated to assess toxicity. BAL fluid was analyzed for lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) to assess pulmonary toxicity. Exposures to ZnO or quartz particles produced transient dose-dependant increase in BAL fluid LDH and ALP activities at all post exposure periods. Blood samples were analyzed for the tissue damage biomarkers to assess extrapulmonary toxicity. Histopathological examination of lung, liver and kidneys revealed dose-dependent degeneration and necrosis which worsened at 1 week post-instillation periods but recovered at 1 month post instillation. Histopathological examination of rat pancreas, heart, and brain exposed to quartz or ZnO particles showed no marked changes. Data suggest the instillation of ZnO nanoparticles produced a greater pulmonary toxicity in rats comparable with quartz; and extrapulmonary toxicities of these ZnO nanoparticles might be due to translocation into liver and kidney. 相似文献
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虽然人类社会不断进步发展,但大量工业和自然排放也导致了严重的空气污染。大气颗粒物是大气污染物的主要成分之一,黑碳是其中的重要组成成分,被国际癌症研究机构(IARC)归类为2B类致癌物。黑碳可以吸附其他致癌物质,会对环境和人体健康产生不利影响,因此黑碳暴露对人类的危害得到越来越多的重视。空气中黑碳的水平与心血管、呼吸和神经系统疾病的发生都有关系;黑碳主要通过引起氧化应激和炎症反应,诱发基因突变等一系列损伤。虽然现今对于黑碳健康效应的研究已取得了一些进展,但研究多数处于起步阶段,且仅针对黑碳本身进行单独研究,未来还需要加强开展对黑碳和其他污染物联合毒性效应及机制的研究。本综述主要针对近年来已开展的研究进行了总结归纳。 相似文献